Researchers at the University of Southern California were recently able to reverse the symptoms of Alzheimer’s disease in animals using two nutritional compounds.
The study involved four groups of mice with Alzheimer’s and an equal number of healthy animals.
Mentally healthy animals performed as expected, but impaired ones exhibited behaviors analogous to humans with Alzheimer’s disease.
Over three months, the diet of the Alzheimer’s animals was supplemented with epigallocatechin-3 gallate (EGCG, or green tea extract) and ferulic acid (FA), a plant sterol complex found in carrots, tomatoes, rice, wheat, and oats. (J Biol Chem 2019 Feb 22;294(8):2714–31)
The combination of these compounds appeared to reduce nerve inflammation and oxidative damage in the brain, which are two of the key characteristics of Alzheimer’s disease. The compounds also appeared to block the process that leads to the formation of amyloid plaques that gum up the brain in Alzheimer’s patients.
EGCG and FA were given at the human equivalent dosage of 30 milligrams for every 2.2 pounds of body weight. So, for someone weighing 150 pounds, the daily dosage would be 2 grams (2,000 milligrams) daily of each compound.
There are numerous supplement suppliers that market green tea extract. But Ferulic acid is a lesser-known compound and not as widely available. The company Source Naturals sells 250-milligram tablets of Trans-Ferulic Acid (same thing) in a 60-count bottle available on Amazon.com.
There have been earlier animal studies demonstrating its safety and effectiveness as a scavenger of free radicals. It is widely used in many skin care formulations to help delay skin aging due to sun exposure. In several countries, it is also used as a food additive to prevent fats from going rancid.
Other studies have indicated that oral ferulic acid may be able to prevent/treat a wide variety of diseases including cancer, diabetes, hyperlipidemia, high blood pressure, fatty liver, hypercalciuria, kidney stones, and heart disease.
Another study also focused on FA for preventing Alzheimer’s disease in animals. In that study, the compound was found to have a protective effect and the researchers commented that it could be a useful preventative agent against the disease. (Drugs Exp Clin Res 2001;27(1):17– 26) (Br J Pharmacol 2001 May;133(1):89–96)
Both nutrients are harmless so it is a no brainer. No pun intended. You can also use a much lower dosage as a preventative.
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